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KMID : 0352819880040010085
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Kosin Medical Journal
1988 Volume.4 No. 1 p.85 ~ p.91
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Transfer of Immunity by Serum and Lymphoid cells immunized with clonorchis sinensis
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Abstract
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To study the transfer of immunity against the Clowchis sinensis, the oriental liver fluke, in ICR mice, 30 donor mice were received per os and intraperitoneally with 20 metacercariae and excysted larvae.
All donor mice were killed by the neck dislocation after 30 days, and then serum and lymphoid cells were made from each donor group.
Four groups of the recipient mice were immunized with serum and lymphoid cells from the donor group I and II. 1 day after the primary immunization, all recipient mice were challenged orally with 20 metacercariae of C. sinensis, and killed 30 days after the challenge infection.
The obtained results from this study were as follows.
1 . The serum provided from the donor group I(per os infection) and II(I. p. infection) did not transfer the immunity to the same kind of mice.
2. The lymphoid cells obtained from the donor group I also could not protect the recipient mice from the challenge infection to worm burden and Eggs Per Gram in the feces.
3. Significant protection against the challenge infection with 20 metacercariae of C. sinensis was conferred on the same kind of ICR
mice by the passive transfer of the lymphoid cells derived from the donor group II.
4. Number of plaque forming cells per spleen (PFC/spleen) accorded with the results of the transfer study.
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KEYWORD
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